Phosphate homeostasis in the yeast Saccharomyces cerevisiae, the key role of the SPX domain‐containing proteins
Copyright policy )Phosphate homeostasis in the yeast Saccharomyces cerevisiae, the key role of the SPX domain‐containing proteins
In the yeast Saccharomyces cerevisiae, a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starvation induced genes, acting to optimize Pi uptake and utilization. Among these, a subset of proteins containing the SPX domain has been shown to be key regulators of Pi homeostasis. In this review, we summarize the recent progresses in elucidating the mechanisms controlling Pi homeostasis in yeast, focusing on the key roles of the SPX domain‐containing proteins in these processes, as well as describing the future challenges and opportunities in this fast‐moving field.
- State Key Laboratory of Plant Physiology and Biochemistry China (People's Republic of)
- La Trobe University Australia
- China Agricultural University China (People's Republic of)
- Zhejiang University China (People's Republic of)
- University of Western Australia Australia
SPX domain, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Phosphoric Diester Hydrolases, Genes, Fungal, Molecular Sequence Data, Vesicular Transport Proteins, Saccharomyces cerevisiae, Models, Biological, Phosphates, Protein Structure, Tertiary, Phosphate homeostasis, Homeostasis, Phosphate Transport Proteins, Budding yeast, Amino Acid Sequence, Phosphate starvation, Molecular Chaperones
SPX domain, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Phosphoric Diester Hydrolases, Genes, Fungal, Molecular Sequence Data, Vesicular Transport Proteins, Saccharomyces cerevisiae, Models, Biological, Phosphates, Protein Structure, Tertiary, Phosphate homeostasis, Homeostasis, Phosphate Transport Proteins, Budding yeast, Amino Acid Sequence, Phosphate starvation, Molecular Chaperones
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