β-Catenin Expression Enhances IL-7 Receptor Signaling in Thymocytes during Positive Selection
Copyright policy )β-Catenin Expression Enhances IL-7 Receptor Signaling in Thymocytes during Positive Selection
Abstract Differentiation of CD4+CD8+ double-positive thymocytes into CD8+ single-positive (SP) thymocytes is regulated by TCR and cytokine receptor signals. Previously, we have shown that expression of stabilized β-catenin, the major transcriptional cofactor of T cell factor, results in increase in both CD4SP and CD8SP thymocytes with a preferential effect on CD8SP thymocytes. In this report, using mice expressing stabilized β-catenin and mice with T cell specific deletion of β-catenin, we show that β-catenin expression augments IL-7Rα-chain expression and down-regulates suppressor of cytokine signaling-1 expression in thymocytes undergoing positive selection. Consequently, β-catenin expression augments IL-7R signaling in thymocytes during positive selection and promotes the development of CD8SP thymocytes.
- National Institute of Health Pakistan
- National Institute on Aging United States
- National Institutes of Health United States
Mice, Knockout, Receptors, Interleukin-7, CD8 Antigens, Down-Regulation, Cell Differentiation, Mice, Transgenic, Suppressor of Cytokine Signaling Proteins, Thymus Gland, CD8-Positive T-Lymphocytes, Mice, Suppressor of Cytokine Signaling 1 Protein, Adjuvants, Immunologic, T-Lymphocyte Subsets, CD4 Antigens, STAT5 Transcription Factor, Animals, Lymphocyte Count, Cells, Cultured, beta Catenin, Signal Transduction
Mice, Knockout, Receptors, Interleukin-7, CD8 Antigens, Down-Regulation, Cell Differentiation, Mice, Transgenic, Suppressor of Cytokine Signaling Proteins, Thymus Gland, CD8-Positive T-Lymphocytes, Mice, Suppressor of Cytokine Signaling 1 Protein, Adjuvants, Immunologic, T-Lymphocyte Subsets, CD4 Antigens, STAT5 Transcription Factor, Animals, Lymphocyte Count, Cells, Cultured, beta Catenin, Signal Transduction
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