DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study
Copyright policy )DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study
This study examined the possible association between the polymorphism in the dopamine receptor DRD4 gene and response to risperidone among 24 Israeli Jewish adolescent inpatients with first-episode schizophrenia. Response was categorically determined by a change of >40% on the Brief Psychiatric Rating Scale (BPRS). No significant association was found between the DRD4 genotype and clinical response, although carriers of <7 repeat alleles demonstrated higher response rate (10/20 vs. 0/4, P=0.11). Studies in larger groups of adolescent schizophrenia patients are warranted to clarify the possible association between DRD4 exon III repeat alleles and the response to risperidone.
- Yale University United States
- Rabin Medical Center Israel
- Tel Aviv University Israel
- Clalit Health Services Israel
- Geha Mental Health Center Israel
Male, Psychiatric Status Rating Scales, Polymorphism, Genetic, Adolescent, Receptors, Dopamine D2, Receptors, Dopamine D4, Pilot Projects, DNA, Exons, Risperidone, Gene Frequency, Pharmacogenetics, Schizophrenia, Humans, Female, Israel, Alleles, Antipsychotic Agents
Male, Psychiatric Status Rating Scales, Polymorphism, Genetic, Adolescent, Receptors, Dopamine D2, Receptors, Dopamine D4, Pilot Projects, DNA, Exons, Risperidone, Gene Frequency, Pharmacogenetics, Schizophrenia, Humans, Female, Israel, Alleles, Antipsychotic Agents
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).40 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!