Polymorphisms inTLR1, TLR6andTLR10genes and the risk of Graves’ disease
Copyright policy )Polymorphisms inTLR1, TLR6andTLR10genes and the risk of Graves’ disease
Graves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll-like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD in Chinese Cantonese population. Seven single nucleotide polymorphisms (i.e. rs4833095 and rs5743565 in TLR1; rs5743808 in TLR6; and rs4504265, rs11466655, rs11096957 and rs10856839 in TLR10) were evaluated in 332 GD patients and 351 unrelated controls from Chinese Cantonese population. SNP rs5743565 in TLR1 conferred a protective effect against GD. The minor allele G of rs5743565 decreased the risk of GD in all cases (odds ratio; ORG vs. A=0.72 (0.58-0.91); p=0.005; ptrend=0.004) and early onset patients (ORG vs. A=0.72 (0.56-0.91); p=0.007; ptrend=0.006). This study provided evidence that genetic variation rs5743565 in TLR1 might be associated with the decreased susceptibility of GD.
- Jinan University China (People's Republic of)
- University of Jinan China (People's Republic of)
- First Affiliated Hospital of Jinan University China (People's Republic of)
- ShenZhen People’s Hospital China (People's Republic of)
Adult, Male, Risk, Gene Expression, Polymorphism, Single Nucleotide, Toll-Like Receptor 1, Graves Disease, Linkage Disequilibrium, Toll-Like Receptor 6, Gene Frequency, Haplotypes, Case-Control Studies, Multigene Family, Toll-Like Receptor 10, Humans, Female, Genetic Predisposition to Disease, Alleles
Adult, Male, Risk, Gene Expression, Polymorphism, Single Nucleotide, Toll-Like Receptor 1, Graves Disease, Linkage Disequilibrium, Toll-Like Receptor 6, Gene Frequency, Haplotypes, Case-Control Studies, Multigene Family, Toll-Like Receptor 10, Humans, Female, Genetic Predisposition to Disease, Alleles
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