Expression and functions of adenylyl cyclases in the CNS
Copyright policy )Expression and functions of adenylyl cyclases in the CNS
AbstractAdenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce the classification and structure of ADCYs, followed by a discussion of the regulation of mammalian ADCYs (ADCY1-10). Next, the expression and function of each mammalian ADCY isoform are summarized in a region/cell-specific manner. Furthermore, the effects of GPCR-ADCY signaling on blood–brain barrier (BBB) integrity are reviewed. Last, current challenges and future directions are discussed. We aim to provide a succinct review on ADCYs to foster new research in the future.
- University of Florida United States
- University of South Florida - University of South Florida, Tampa
- University of South Florida United States
- Florida Southern College United States
Central Nervous System, Mammals, Adenylyl cyclases, Review, Blood–brain barrier, G-protein coupled receptors, Animals, Neurology. Diseases of the nervous system, CNS, RC346-429, Adenylyl Cyclases
Central Nervous System, Mammals, Adenylyl cyclases, Review, Blood–brain barrier, G-protein coupled receptors, Animals, Neurology. Diseases of the nervous system, CNS, RC346-429, Adenylyl Cyclases
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