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Linkage Mapping of 40 Randomly Isolated Liver cDNA Clones in the Mouse

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1993 English Publisher:Elsevier BVJournal:Genomics, volume 18, pages 295-307 (issn: 0888-7543,

Authors: Karen L. Svenson; Margarete Mehrabian; Craig H Warden; Robert S. Sparkes; Moon Young Yoon; Yu Rong Xia; Kong yuan He; +3 Authors

doi: 10.1006/geno.1993.1469

pmid: 8288233

Linkage Mapping of 40 Randomly Isolated Liver cDNA Clones in the Mouse

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Abstract

We report the chromosomal mapping of 43 loci for 40 randomly isolated mouse liver cDNA clones by linkage analysis in an interspecific backcross of ((C57BL/6J x Mus spretus) x C57BL/6J). The clones were sequenced from both sides and a subset was examined for expression in various mouse tissues. Fifteen of the 40 mapped cDNA clones are either identical or strongly related to known sequences in GenBank, while 25 represent new genes. Additional loci mapped in this cross include 53 simple sequence repeat polymorphisms and 40 restriction fragment length variants from previously characterized cDNA markers. Nine homologous human genes were identified for 7 mouse liver cDNA clones. One clone that maps to mouse chromosome 3 (D3Ucla1) identified a novel homologous segment (synteny) on human chromosome 18q23 (D18S372E). These studies provide linkage mapping and initial characterization of random cDNA clones that may provide a resource for the positional candidate cloning of disease genes.

Related Organizations

University of Chicago
United States
University of California, Los Angeles
United States

Keywords

DNA, Complementary, Chromosome Mapping, Hybrid Cells, Cell Line, Mice, Inbred C57BL, Mice, Liver, Mice, Inbred CBA, Animals, Humans, Female, Cloning, Molecular, Repetitive Sequences, Nucleic Acid

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