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The mouse dead-end gene isoform α is necessary for germ cell and embryonic viability

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2007 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 355, pages 194-199 (issn: 0006-291X,

Authors: Ming Zhao; Chitralekha Bhattacharya; Sita Aggarwal; Angabin Matin; Rui Zhu; Marvin L. Meistrich; Madhu Kumar;

doi: 10.1016/j.bbrc.2007.01.138

pmid: 17291453

pmc: PMC1855146

The mouse dead-end gene isoform α is necessary for germ cell and embryonic viability

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Abstract

Inactivation of the dead-end (Dnd1) gene in the Ter mouse strain results in depletion of primordial germ cells (PGCs) so that mice become sterile. However, on the 129 mouse strain background, loss of Dnd1 also increases testicular germ cell tumor incidence in parallel to PGC depletion. We report that inactivation of Dnd1 also affects embryonic viability in the 129 strain. Mouse Dnd1 encodes two protein isoforms, DND1-isoform alpha (DND1-alpha) and DND1-isoform beta (DND1-beta). Using isoform-specific antibodies, we determined DND1-alpha is expressed in embryos and embryonic gonads whereas DND1-beta expression is restricted to germ cells of the adult testis. Our data implicate DND1-alpha isoform to be necessary for germ cell viability and therefore its loss in Ter mice results in PGC depletion, germ cell tumor development and partial embryonic lethality in the 129 strain.

Related Organizations

The University of Texas MD Anderson Cancer Center
United States

Keywords

Male, DNA, Complementary, Sertoli Cells, Cell Survival, Reverse Transcriptase Polymerase Chain Reaction, Embryonic Development, Mice, Inbred Strains, Antibodies, Recombinant Proteins, Neoplasm Proteins, Mice, Germ Cells, Pregnancy, Embryo Loss, Animals, Protein Isoforms, Female, Cells, Cultured

8 Research products, page 1 of 1

Uncharacterized protein
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Tyrosinase, isoform CRA_b
2017IsRelatedTo
Tyrosinase
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Dead end protein homolog 1
2017IsRelatedTo
Uncharacterized protein
2017IsRelatedTo
Tyrosinase
2017IsRelatedTo
Uncharacterized protein
2017IsRelatedTo
Tyrosinase
2017IsRelatedTo

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