Elevation of Gas6 protein concentration in cerebrospinal fluid of patients with chronic inflammatory demyelinating polyneuropathy (CIDP)
Copyright policy )Elevation of Gas6 protein concentration in cerebrospinal fluid of patients with chronic inflammatory demyelinating polyneuropathy (CIDP)
Gas6 enhances survival of Schwann cells and neurons in vitro and participates in autoimmunity in animal models. Since its concentration in human cerebrospinal fluid (CSF) is unknown, we measured it in samples from patients with non-inflammatory/non-autoimmune neurological diseases (NINAD) and autoimmune polyneuropathies.Samples collected after informed consent during diagnostic lumbar puncture in the period 1999-2006 were stored at -30 degrees C. We considered subjects with NINAD (stroke, ALS, headache, psychiatric conditions simulating neurological diseases, otologic dizziness) or with Guillain-Barré syndrome (GBS) or CIDP. CSF and plasma total protein and age were obtained from clinical records. Gas6 was measured with an ELISA developed and validated in our laboratory (inter-, intra-assay CVs 0.1).Gas6 is detectable in CSF and may be involved in chronic autoimmune demyelination or myelin repair.
Adult, Aged, 80 and over, Male, 610, Reproducibility of Results, Enzyme-Linked Immunosorbent Assay, Middle Aged, Guillain-Barre Syndrome, Gene Expression Regulation, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, 616, Humans, Intercellular Signaling Peptides and Proteins, Regression Analysis, Female, Aged, Retrospective Studies
Adult, Aged, 80 and over, Male, 610, Reproducibility of Results, Enzyme-Linked Immunosorbent Assay, Middle Aged, Guillain-Barre Syndrome, Gene Expression Regulation, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, 616, Humans, Intercellular Signaling Peptides and Proteins, Regression Analysis, Female, Aged, Retrospective Studies
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