The soluble N-terminal autoinhibitory module of the A1 domain in von Willebrand factor partially suppresses its catch bond with glycoprotein Ibα in a sandwich complex
Copyright policy )ARC| Discovery Projects - Grant ID: DP200101970 ,
ARC| Discovery Early Career Researcher Award - Grant ID: DE190100609
Yunduo Charles Zhao; Zhenhai Li; Lining Arnold Ju;
The soluble N-terminal autoinhibitory module of the A1 domain in von Willebrand factor partially suppresses its catch bond with glycoprotein Ibα in a sandwich complex
The von Willebrand factor A1 domain-derived polypeptide sequence Q1238-E1260 forms a hairpin-like structure in trans. Soluble Q1238-E1260 partially inhibits A1–GPIbα binding while retaining its catch-bond behavior in a sandwich complex.
- Georgia Institute of Technology United States
- Shanghai University China (People's Republic of)
- The Heart Research Institute Australia
- University of Sydney Australia
- Emory University United States
Blood Platelets, Molecular Docking Simulation, Platelet Glycoprotein GPIb-IX Complex, von Willebrand Factor, COVID-19, Humans, Protein Binding
Blood Platelets, Molecular Docking Simulation, Platelet Glycoprotein GPIb-IX Complex, von Willebrand Factor, COVID-19, Humans, Protein Binding
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 3
Top 10%
Average
Average
Beta
Funded by
Related to Research communities