BID, a Proapoptotic BCL-2 Family Member, Is Localized to Mouse Chromosome 6 and Human Chromosome 22q11
Copyright policy )BID, a Proapoptotic BCL-2 Family Member, Is Localized to Mouse Chromosome 6 and Human Chromosome 22q11
BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single alpha-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouse Bid and human BID genomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus. Fluorescence in situ hybridization analysis localized human BID to a syntenic human region, chromosome 22q11, close to the BCR-1 gene.
- National Cancer Institute United States
- University of Mary United States
- Howard Hughes Medical Institute United States
- Washington University in St. Louis United States
Chromosomes, Human, Pair 22, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, Exons, Introns, Mice, Inbred C57BL, Mice, Animals, Humans, Carrier Proteins, In Situ Hybridization, Fluorescence, BH3 Interacting Domain Death Agonist Protein
Chromosomes, Human, Pair 22, Molecular Sequence Data, Chromosome Mapping, Mice, Inbred Strains, Exons, Introns, Mice, Inbred C57BL, Mice, Animals, Humans, Carrier Proteins, In Situ Hybridization, Fluorescence, BH3 Interacting Domain Death Agonist Protein
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