Receptor-Associated Resistance to Growth Hormone-Releasing Factor in Dwarf "Little" Mice
Copyright policy )Receptor-Associated Resistance to Growth Hormone-Releasing Factor in Dwarf "Little" Mice
Anterior pituitaries from the dwarf mouse strain "little" did not release growth hormone or accumulate adenosine 3′,5′-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing factor (GRF). Dibutyryl cyclic AMP, as well as the adenylate cyclase stimulators forskolin and cholera toxin, markedly stimulated growth hormone (GH) release. The basis of the GH deficiency in the little mouse may therefore be a defect in an early stage of GRF-stimulated GH release related either to receptor binding or to the function of the hormone-receptor complex.
- University of Cincinnati United States
- Jackson Laboratory United States
- University of Cincinnati Medical Center United States
- University System of Ohio United States
Receptors, Neuropeptide, 570, 610, Receptors, Cell Surface, Somatotropin-Releasing-Hormone: ph, pp, Growth Hormone-Releasing Hormone, Mice, Receptors, Pituitary Hormone-Regulating Hormone, Pituitary Gland, Anterior, SUPPORT-U-S-GOVT-P-H-S, Medicine and Health Sciences, Cyclic AMP, Animals, Humans, Receptors-Endogenous-Substances: ph, Dwarfism, Pituitary, SUPPORT-NON-U-S-GOVT, Dwarfism-Pituitary: pp, Animal, me, Mice-Inbred-C57BL, Colforsin, Life Sciences, Mice, Mutant Strains, Pituitary-Gland-Anterior: de, Mice, Inbred C57BL, an, Female, Forskolin, Mice-Mutant-Strains: ph, pa, Human
Receptors, Neuropeptide, 570, 610, Receptors, Cell Surface, Somatotropin-Releasing-Hormone: ph, pp, Growth Hormone-Releasing Hormone, Mice, Receptors, Pituitary Hormone-Regulating Hormone, Pituitary Gland, Anterior, SUPPORT-U-S-GOVT-P-H-S, Medicine and Health Sciences, Cyclic AMP, Animals, Humans, Receptors-Endogenous-Substances: ph, Dwarfism, Pituitary, SUPPORT-NON-U-S-GOVT, Dwarfism-Pituitary: pp, Animal, me, Mice-Inbred-C57BL, Colforsin, Life Sciences, Mice, Mutant Strains, Pituitary-Gland-Anterior: de, Mice, Inbred C57BL, an, Female, Forskolin, Mice-Mutant-Strains: ph, pa, Human
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