Discovery of thiophene inhibitors of polo-like kinase
Copyright policy )Discovery of thiophene inhibitors of polo-like kinase
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
- GlaxoSmithKline (United States) United States
- Research Triangle Park Foundation United States
Chemistry, Pharmaceutical, Cell Cycle, Molecular Conformation, Mitosis, Cell Cycle Proteins, Thiophenes, Protein Serine-Threonine Kinases, Polo-Like Kinase 1, Inhibitory Concentration 50, Mice, Models, Chemical, Cell Line, Tumor, Drug Design, Proto-Oncogene Proteins, Animals, Humans, Enzyme Inhibitors, Cell Proliferation
Chemistry, Pharmaceutical, Cell Cycle, Molecular Conformation, Mitosis, Cell Cycle Proteins, Thiophenes, Protein Serine-Threonine Kinases, Polo-Like Kinase 1, Inhibitory Concentration 50, Mice, Models, Chemical, Cell Line, Tumor, Drug Design, Proto-Oncogene Proteins, Animals, Humans, Enzyme Inhibitors, Cell Proliferation
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