(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma
Copyright policy )(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma
AbstractAlthough Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting alternative mechanisms for Wnt/β-catenin activation. Recent studies have implicated the (pro)renin receptor ((P)RR) is related to the Wnt/β-catenin signaling pathway. We therefore investigated the possible role of (P)RR in pancreatic carcinogenesis. Plasma s(P)RR levels were significantly (P < 0.0001) higher in patients with PDAC than in healthy matched controls. We also identified aberrant expression of (P)RR in premalignant PanIN and PDAC lesions and all the PDAC cell lines examined. Inhibiting (P)RR with an siRNA attenuated activation of Wnt/β-catenin signaling pathway and reduced the proliferative ability of PDAC cells in vitro and the growth of engrafted tumors in vivo. Loss of (P)RR induced apoptosis of human PDAC cells. This is the first demonstration that (P)RR may be profoundly involved in ductal tumorigenesis in the pancreas.
- Inserm France
- French Institute of Health and Medical Research France
- Kagawa University Japan
- Institut des Sciences Biologiques France
- Tokyo Women's Medical University Japan
Aged, 80 and over, Male, Vacuolar Proton-Translocating ATPases, Carcinogenesis, Receptors, Cell Surface, Middle Aged, Article, Pancreatic Neoplasms, Cell Line, Tumor, Humans, Female, Pancreas, Wnt Signaling Pathway, Aged, Carcinoma, Pancreatic Ductal
Aged, 80 and over, Male, Vacuolar Proton-Translocating ATPases, Carcinogenesis, Receptors, Cell Surface, Middle Aged, Article, Pancreatic Neoplasms, Cell Line, Tumor, Humans, Female, Pancreas, Wnt Signaling Pathway, Aged, Carcinoma, Pancreatic Ductal
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).59 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!