The enemy within: intronic miR-26b represses its host gene,ctdsp2, to regulate neurogenesis
Copyright policy )The enemy within: intronic miR-26b represses its host gene,ctdsp2, to regulate neurogenesis
Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue ofGenes & Development, Dill and colleagues (pp. 25–30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene,ctdsp2.
- Salk Institute for Biological Studies United States
Neurons, MicroRNAs, Phosphoprotein Phosphatases, Animals, Gene Expression Regulation, Developmental, Cell Differentiation, Zebrafish Proteins
Neurons, MicroRNAs, Phosphoprotein Phosphatases, Animals, Gene Expression Regulation, Developmental, Cell Differentiation, Zebrafish Proteins
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