Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1–3 in angiogenesis
Copyright policy )Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1–3 in angiogenesis
In a comparison of embryonic brain expression patterns of lysophosphatidic acid and sphingosine 1‐phosphate receptor genes (lpa1–3 and s1p1–5 , respectively), transcripts detected by Northern blot were subsequently localized using in situ hybridization. We found striking s1p1 expression adjacent to several ventricles. Near the lateral ventricle, s1p1 expression was temporally and spatially coincident with neurogenesis and overlapped with lpa1 in the neocortical area. We also observed a widespread diffuse pattern for lpa2–3 and a scattered punctate pattern for s1p1–3 . The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p1 influences neurogenesis and s1p1–3 influence angiogenesis in the developing brain.
- University of California, San Diego United States
- University of California, San Diego United States
Male, PECAM-1, Neovascularization, Physiologic, Antigens, CD34, Receptors, Cell Surface, S1P, Receptors, G-Protein-Coupled, Mice, Mesencephalon, Animals, RNA, Messenger, In Situ Hybridization, Cerebral Cortex, Neurons, Mice, Inbred BALB C, Neovascularization, Pathologic, Brain, Cerebral cortex, Blotting, Northern, LPA, lpB, Platelet Endothelial Cell Adhesion Molecule-1, Bromodeoxyuridine, G-protein coupled receptor, CD34, Endothelium, Vascular, EDG, Lysophospholipids, Cell Division
Male, PECAM-1, Neovascularization, Physiologic, Antigens, CD34, Receptors, Cell Surface, S1P, Receptors, G-Protein-Coupled, Mice, Mesencephalon, Animals, RNA, Messenger, In Situ Hybridization, Cerebral Cortex, Neurons, Mice, Inbred BALB C, Neovascularization, Pathologic, Brain, Cerebral cortex, Blotting, Northern, LPA, lpB, Platelet Endothelial Cell Adhesion Molecule-1, Bromodeoxyuridine, G-protein coupled receptor, CD34, Endothelium, Vascular, EDG, Lysophospholipids, Cell Division
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