Structure of the RSC complex bound to the nucleosome
Copyright policy )Structure of the RSC complex bound to the nucleosome
The architecture of the RSC complex RSC is a Snf2-family chromatin remodeler complex that controls the promoter architecture of most of the genes in yeast. Using single-particle cryo–electron microscopy, Ye et al. determined the structure of RSC bound to the nucleosome. The structure reveals the modular architecture of RSC, shows how RSC engages the nucleosome, and explains the remodeling directionality. RSC shows strong similarities to homologous human complexes that are frequently mutated in cancers, and this structure provides valuable information for understanding these systems. Science , this issue p. 838
- Peking University China (People's Republic of)
- Peking University China (People's Republic of)
- Tsinghua University China (People's Republic of)
- State Key Laboratory of Membrane Biology China (People's Republic of)
- University of Utah United States
Saccharomyces cerevisiae Proteins, Chromosomal Proteins, Non-Histone, Cryoelectron Microscopy, Cell Cycle Proteins, SMARCB1 Protein, Actins, Chromatin, Nucleosomes, DNA-Binding Proteins, Protein Domains, Transcription Factors
Saccharomyces cerevisiae Proteins, Chromosomal Proteins, Non-Histone, Cryoelectron Microscopy, Cell Cycle Proteins, SMARCB1 Protein, Actins, Chromatin, Nucleosomes, DNA-Binding Proteins, Protein Domains, Transcription Factors
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