KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease
Copyright policy )KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease
Vogt-Koyanagi-Harada (VKH) disease is a putative autoimmune ocular inflammatory disease and is known to be associated with HLA-DR4 and -DR1 in Mestizos. We examined the genes encoding KIR receptors and human leukocyte antigen (HLA) class I ligands in patients with VKH disease and compared to published controls. We found trends toward more group B KIR haplogroups (p=0.059), with more activating KIR genes, in patients compared to controls. All putative activating KIR-HLA combinations were more common in patients, and some inhibitory KIR-HLA combinations were more common in controls, although the differences were not statistically significant. The trends observed in this study are consistent with those reported for other autoimmune diseases.
- University of California, Los Angeles United States
- University of California System United States
- Doheny Eye Institute United States
- University of Southern California United States
Male, HLA-DR Antigens, California, Gene Frequency, Haplotypes, Receptors, KIR, Indians, North American, Humans, Female, Genetic Predisposition to Disease, Protein Interaction Domains and Motifs, Uveomeningoencephalitic Syndrome
Male, HLA-DR Antigens, California, Gene Frequency, Haplotypes, Receptors, KIR, Indians, North American, Humans, Female, Genetic Predisposition to Disease, Protein Interaction Domains and Motifs, Uveomeningoencephalitic Syndrome
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