Identification of eight genes encoding chemokine-like factor superfamily members 1–8 (CKLFSF1–8) by in silico cloning and experimental validation
Copyright policy )Identification of eight genes encoding chemokine-like factor superfamily members 1–8 (CKLFSF1–8) by in silico cloning and experimental validation
TM4SF11 is only 102 kb from the chemokine gene cluster composed of SCYA22, SCYD1, and SCYA17 on chromosome 16q13. CKLF maps on chromosome 16q22. CKLFs have some characteristics associated with the CCL22/MDC, CX3CL1/fractalkine, CCL17/TARC, and TM4SF proteins. Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified eight novel genes designated chemokine-like factor superfamily members 1-8 (CKLFSF1-8). CKLFSF1-8 form gene clusters; the sequence identities between CKLF2 and CKLFSF1-8 are from 12.5 to 39.7%. Most of the CKLFSFs have alternative RNA splicing forms. CKLFSF1 has a CC motif and higher sequence similarity with chemokines than with any of the other CKLFSFs. CKLFSF8 shares 39.3% amino acid identity with TM4SF11. CKLFSF1 links the CKLFSF family with chemokines, and CKLFSF8 links it with TM4SF. The characteristics of CKLFSF2-7 are intermediate between CKLFSF1 and CKLFSF8. This indicates that CKLFSF represents a novel gene family between the SCY and the TM4SF gene families.
- Peking University China (People's Republic of)
- Peking University China (People's Republic of)
MARVEL Domain-Containing Proteins, Myelin and Lymphocyte-Associated Proteolipid Proteins, Proteolipids, Tumor Suppressor Proteins, Molecular Sequence Data, Chromosome Mapping, Membrane Proteins, Sequence Homology, Nerve Tissue Proteins, Alternative Splicing, Chemokines, CC, Multigene Family, Humans, Amino Acid Sequence, Chemokine CCL17, Chemokines, Cloning, Molecular, Databases, Protein
MARVEL Domain-Containing Proteins, Myelin and Lymphocyte-Associated Proteolipid Proteins, Proteolipids, Tumor Suppressor Proteins, Molecular Sequence Data, Chromosome Mapping, Membrane Proteins, Sequence Homology, Nerve Tissue Proteins, Alternative Splicing, Chemokines, CC, Multigene Family, Humans, Amino Acid Sequence, Chemokine CCL17, Chemokines, Cloning, Molecular, Databases, Protein
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