Evidence for A1 and A3 receptors mediating adenosine-induced intracellular calcium release in the dorsal root ganglion neurons by using confocal microscopy imaging
Copyright policy )Evidence for A1 and A3 receptors mediating adenosine-induced intracellular calcium release in the dorsal root ganglion neurons by using confocal microscopy imaging
Adenosine exerts a key role in analgesia. In the present study, adenosine-induced Ca(2+) responses were revealed by using confocal microscopy imaging in the rat dorsal root ganglia (DRG) neurons in vitro. Our results showed that adenosine could evoke increases in the intracellular Ca(2+) concentration in the DRG neurons. In addition, by application of selective receptor antagonists, two types of receptors, A1R and A3R, were identified to be involved in the adenosine-induced Ca(2+) release from intracellular stores in neurons. Altogether, these results suggest that confocal microscopy imaging combined with fluorescent dyes could help to detect the analgesic-induced ion signaling in single cell.
- Fujian Normal University China (People's Republic of)
Neurons, Adenosine, Microscopy, Confocal, Receptor, Adenosine A1, Optical Imaging, Receptor, Adenosine A3, Intracellular Space, Adenosine A3 Receptor Antagonists, Adenosine A1 Receptor Antagonists, Rats, Sprague-Dawley, Ganglia, Spinal, Animals, Calcium, Cells, Cultured
Neurons, Adenosine, Microscopy, Confocal, Receptor, Adenosine A1, Optical Imaging, Receptor, Adenosine A3, Intracellular Space, Adenosine A3 Receptor Antagonists, Adenosine A1 Receptor Antagonists, Rats, Sprague-Dawley, Ganglia, Spinal, Animals, Calcium, Cells, Cultured
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!