Frequent association of alternative splicing of NER, a nuclear hormone receptor gene in cancer tissues
Copyright policy )Frequent association of alternative splicing of NER, a nuclear hormone receptor gene in cancer tissues
We have detected frequent alternative splicing of a gene that encodes NER, a protein homologous to the retinoic acid receptors, in cancer cells. Western and immunohistochemical analyses disclosed accumulation of a large amount of the aberrant NER product, generated by alternative splicing that caused skipping of an exon corresponding to the DNA-binding domain, in the nucleoli of cells of cancer cell lines and primary cancer tissues. The aberrant protein was detected in 116 of 228 primary cancers developed in various tissues including breast and colon, but was absent in the corresponding normal tissues; it was also detected in 31 of 39 cancer cell lines. This observation may imply that the aberrant NER product has some relation to the development and/or progression of cancers in a variety of human tissues.
- Seoul National University Korea (Republic of)
- University of Tokyo Japan
- Tohoku University Japan
- Kyoto University Japan
Ovarian Neoplasms, Esophageal Neoplasms, Blotting, Western, Antibodies, Monoclonal, Receptors, Cytoplasmic and Nuclear, Breast Neoplasms, Orphan Nuclear Receptors, Immunohistochemistry, Polymerase Chain Reaction, Alternative Splicing, Neoplasms, Colonic Neoplasms, Disease Progression, Humans, Female, Carrier Proteins, Colorectal Neoplasms, DNA Primers, HeLa Cells, Liver X Receptors
Ovarian Neoplasms, Esophageal Neoplasms, Blotting, Western, Antibodies, Monoclonal, Receptors, Cytoplasmic and Nuclear, Breast Neoplasms, Orphan Nuclear Receptors, Immunohistochemistry, Polymerase Chain Reaction, Alternative Splicing, Neoplasms, Colonic Neoplasms, Disease Progression, Humans, Female, Carrier Proteins, Colorectal Neoplasms, DNA Primers, HeLa Cells, Liver X Receptors
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