A role for Dicer in immune regulation
Copyright policy )A role for Dicer in immune regulation
Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor β. These results suggest that T reg cell development involves Dicer-generated RNAs.
- University of California System United States
- Wellcome / CRUK Gurdon Institute United Kingdom
- University of Cambridge - Department of Biochemistry United Kingdom
- University of California, San Francisco United States
- Imperial College London United Kingdom
foxp3 gene, Ribonuclease III, MICRORNAS, T-Lymphocytes, Research & Experimental Medicine, MOUSE, Medical and Health Sciences, T-Lymphocytes, Regulatory, Mice, ribonucleases, antigens, Transforming Growth Factor beta, T-CELL DEVELOPMENT, 11 Medical and Health Sciences, Cells, Cultured, Cultured, Research & Experimental, INDUCTION, TGF-BETA, Cell Differentiation, Forkhead Transcription Factors, pancreatic ribonuclease, MICROPROCESSOR COMPLEX, Articles, Regulatory, DIFFERENTIATION, Medicine, Research & Experimental, Medicine, helper-inducer t-lymphocytes, Life Sciences & Biomedicine, Biotechnology, thymus gland, Cells, enzymes, Immunology, 610, endoribonucleases, Thymus Gland, TARGETS, Genetics, Animals, micrornas, t-lymphocytes, Science & Technology, TRANSCRIPTION FACTOR FOXP3, LINEAGE CHOICE, cd25, MicroRNAs
foxp3 gene, Ribonuclease III, MICRORNAS, T-Lymphocytes, Research & Experimental Medicine, MOUSE, Medical and Health Sciences, T-Lymphocytes, Regulatory, Mice, ribonucleases, antigens, Transforming Growth Factor beta, T-CELL DEVELOPMENT, 11 Medical and Health Sciences, Cells, Cultured, Cultured, Research & Experimental, INDUCTION, TGF-BETA, Cell Differentiation, Forkhead Transcription Factors, pancreatic ribonuclease, MICROPROCESSOR COMPLEX, Articles, Regulatory, DIFFERENTIATION, Medicine, Research & Experimental, Medicine, helper-inducer t-lymphocytes, Life Sciences & Biomedicine, Biotechnology, thymus gland, Cells, enzymes, Immunology, 610, endoribonucleases, Thymus Gland, TARGETS, Genetics, Animals, micrornas, t-lymphocytes, Science & Technology, TRANSCRIPTION FACTOR FOXP3, LINEAGE CHOICE, cd25, MicroRNAs
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