Agouti C57BL/6N embryonic stem cells for mouse genetic resources
Copyright policy )Agouti C57BL/6N embryonic stem cells for mouse genetic resources
We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation. These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background.
- Harvard University United States
- Massachusetts Institute of Technology United States
- Wellcome Trust Sanger Institute Wellcome Trust Genome Campus United Kingdom
- University of Cambridge United Kingdom
- University of California System United States
Male, 570, Technology, 1.1 Normal biological development and functioning, Knockout, 610, Stem Cell Research - Embryonic - Non-Human, Mice, Transgenic, Crosses, Regenerative Medicine, Inbred C57BL, Medical and Health Sciences, Polymorphism, Single Nucleotide, Transgenic, Article, Cell Line, Mice, Genetic, Pregnancy, Genetics, Animals, Polymorphism, Hair Color, Crosses, Genetic, Embryonic Stem Cells, Germ-Line Mutation, DNA Primers, Mice, Knockout, Transplantation Chimera, Base Sequence, Single Nucleotide, Biological Sciences, Stem Cell Research, Mice, Mutant Strains, Mutant Strains, Mice, Inbred C57BL, Biological sciences, Genetic Techniques, Gene Targeting, Agouti Signaling Protein, Female, Generic health relevance, Biotechnology, Developmental Biology
Male, 570, Technology, 1.1 Normal biological development and functioning, Knockout, 610, Stem Cell Research - Embryonic - Non-Human, Mice, Transgenic, Crosses, Regenerative Medicine, Inbred C57BL, Medical and Health Sciences, Polymorphism, Single Nucleotide, Transgenic, Article, Cell Line, Mice, Genetic, Pregnancy, Genetics, Animals, Polymorphism, Hair Color, Crosses, Genetic, Embryonic Stem Cells, Germ-Line Mutation, DNA Primers, Mice, Knockout, Transplantation Chimera, Base Sequence, Single Nucleotide, Biological Sciences, Stem Cell Research, Mice, Mutant Strains, Mutant Strains, Mice, Inbred C57BL, Biological sciences, Genetic Techniques, Gene Targeting, Agouti Signaling Protein, Female, Generic health relevance, Biotechnology, Developmental Biology
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