Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos
Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos
In this report, we present the isolation and identification of a zebrafish homolog of the winged helix\forkhead transcription factor Foxj1. Foxj1 was identified in other species but not in zebrafish. Foxj1 was shown in mice to be required in ciliogenesis and left-right asymmetry establishment. Here we present a spatio-temporal expression pattern of zebrafish foxj1, showing that this gene is expressed in dorsal forerunner cells, Kupffers vesicle, the floor plate, pronephric ducts and kidney. This expression pattern is overlapping but different from that of the foxj1.2, the closest related gene in zebrafish. Foxj1 in zebrafish appears to have similar functions as those reported in other species connected to ciliogenesis and left-right asymmetry.
- National Institute of Health Pakistan
- National Institutes of Health United States
Embryo, Nonmammalian, Sequence Homology, Amino Acid, Left-Right Determination Factors, Molecular Sequence Data, Gene Expression, Forkhead Transcription Factors, Zebrafish Proteins, Animals, Amino Acid Sequence, Cilia, In Situ Hybridization, Phylogeny, Zebrafish
Embryo, Nonmammalian, Sequence Homology, Amino Acid, Left-Right Determination Factors, Molecular Sequence Data, Gene Expression, Forkhead Transcription Factors, Zebrafish Proteins, Animals, Amino Acid Sequence, Cilia, In Situ Hybridization, Phylogeny, Zebrafish
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