Activation of spleen tyrosine kinase is required for TNF‐α‐induced endothelin‐1 upregulation in human aortic endothelial cells
Copyright policy )Activation of spleen tyrosine kinase is required for TNF‐α‐induced endothelin‐1 upregulation in human aortic endothelial cells
Endothelin‐1 (ET‐1) promotes atherosclerosis. We tested whether spleen tyrosine kinase (Syk) mediates tumor necrosis factor‐α (TNF‐α)‐induced ET‐1 upregulation in human aortic endothelial cells (HAECs) and sought to identify the signal pathways involved. TNF‐α‐induced reactive oxygen species (ROS) activated Syk and phosphatidylinositol 3‐kinase (PI3K), which was required for the activation of AP‐1 and subsequent ET‐1 gene transcription. ROS mediated c‐Jun NH2‐terminal kinase (JNK) is also required for AP‐1 activation, but Syk and PI3K regulated AP‐1 activation independently of JNK. Through regulation of ET‐1 production, Syk could be implicated in atherosclerosis.
- University of Ulsan Korea (Republic of)
- Asan Medical Center Korea (Republic of)
- Asan Foundation Korea (Republic of)
- University of Ulsan Korea (Republic of)
Endothelin-1, Tumor Necrosis Factor-alpha, Intracellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, Endothelial Cells, Spleen tyrosine kinase, Protein-Tyrosine Kinases, Atherosclerosis, Tumor necrosis factor-α, Up-Regulation, Enzyme Activation, Transcription Factor AP-1, Phosphatidylinositol 3-Kinases, Humans, Syk Kinase, Enzyme Inhibitors, RNA, Small Interfering, Reactive oxygen species, Reactive Oxygen Species, Activator protein-1, Aorta, Cells, Cultured
Endothelin-1, Tumor Necrosis Factor-alpha, Intracellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, Endothelial Cells, Spleen tyrosine kinase, Protein-Tyrosine Kinases, Atherosclerosis, Tumor necrosis factor-α, Up-Regulation, Enzyme Activation, Transcription Factor AP-1, Phosphatidylinositol 3-Kinases, Humans, Syk Kinase, Enzyme Inhibitors, RNA, Small Interfering, Reactive oxygen species, Reactive Oxygen Species, Activator protein-1, Aorta, Cells, Cultured
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