Structure, Expression, and Chromosome Mapping of LATS2, a Mammalian Homologue of the Drosophila Tumor Suppressor Gene lats/warts
Copyright policy )Structure, Expression, and Chromosome Mapping of LATS2, a Mammalian Homologue of the Drosophila Tumor Suppressor Gene lats/warts
We have cloned and characterized LATS2, a novel mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Northern blot analysis showed ubiquitous expression of mouse LATS2 (MmLATS2) mRNA, whereas expression of human LATS2 (HsLATS2) mRNA was enhanced in skeletal muscle and heart. Immunoblotting analysis of fractionated cell lysates showed HsLats2 to be a nuclear protein. We mapped the MmLATS2 gene to mouse chromosome 14 by interspecific backcross analysis. We also mapped the HsLATS2 gene (by fluorescence in situ hybridization) to the 13q11-q12 region, in which a loss of heterozygosity has been frequently observed in many primary cancers and to which the tumor suppressor genes RB and BRCA2 have also been mapped.
- Toyobo Japan
- Osaka University Japan
DNA, Complementary, Chromosomes, Human, Pair 13, Sequence Homology, Amino Acid, Tumor Suppressor Proteins, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Genes, Insect, Protein Serine-Threonine Kinases, Mice, Animals, Drosophila Proteins, Humans, Drosophila, Genes, Tumor Suppressor, Amino Acid Sequence, RNA, Messenger, Protein Kinases, In Situ Hybridization, Fluorescence, Phylogeny
DNA, Complementary, Chromosomes, Human, Pair 13, Sequence Homology, Amino Acid, Tumor Suppressor Proteins, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Genes, Insect, Protein Serine-Threonine Kinases, Mice, Animals, Drosophila Proteins, Humans, Drosophila, Genes, Tumor Suppressor, Amino Acid Sequence, RNA, Messenger, Protein Kinases, In Situ Hybridization, Fluorescence, Phylogeny
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