Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries
Copyright policy )Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries
Extracellular UDP‐glucose can activate the purinergic P2Y14 receptor. The aim of the present study was to examine the physiological importance of P2Y14 receptors in the vasculature. The data presented herein show that UDP‐glucose causes contraction in mouse coronary and basilar arteries. The EC50 values and immunohistochemistry illustrated the strongest P2Y14 receptor expression in the basilar artery. In the presence of pertussis toxin, UDP‐glucose inhibited contraction in coronary arteries and in the basilar artery it surprisingly caused relaxation. After organ culture of the coronary artery, the EC50 value decreased and an increased staining for the P2Y14 receptor was observed, showing receptor plasticity.
- University of Copenhagen Denmark
- University of Copenhagen Denmark
- Copenhagen University Hospital Denmark
Male, Uridine Diphosphate Glucose, In Vitro Techniques, Coronary artery, Mice, Purinergic P2Y, Receptors, Animals, P2Y14, Inbred BALB C, Receptor upregulation, Mice, Inbred BALB C, Cerebral Arteries, Coronary Vessels, Up-Regulation, Basilar artery, Pertussis Toxin, P2Y2 KO, Receptors, Purinergic P2Y, Female, Purinergic receptors, Muscle Contraction
Male, Uridine Diphosphate Glucose, In Vitro Techniques, Coronary artery, Mice, Purinergic P2Y, Receptors, Animals, P2Y14, Inbred BALB C, Receptor upregulation, Mice, Inbred BALB C, Cerebral Arteries, Coronary Vessels, Up-Regulation, Basilar artery, Pertussis Toxin, P2Y2 KO, Receptors, Purinergic P2Y, Female, Purinergic receptors, Muscle Contraction
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