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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Preprint 26 Jul 2016 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Advances, volume 3 (eissn: 2375-2548, Copyright policy )Funded by:NIH | Molecular characterizatio..., NIH | Biomechanical analysis of..., NIH | Myosin Movement in Vitro ...
Authors: Masataka Kawana; Saswata S. Sarkar; Shirley Sutton; Kathleen M. Ruppel; James A. Spudich;

doi: 10.1126/sciadv.1601959 , 10.1101/065649

pmid: 28246639

pmc: PMC5302870

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

Abstract

Converter HCM mutations cause only small changes in the biophysics of myosin, suggesting an alternative mechanism for hypercontractility.

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Keywords

Ventricular Myosins, Amino Acid Substitution, Genetic Diseases, Inborn, Mutation, Missense, Humans, Cardiomegaly, Research Articles

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 78
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
78
Top 1%
Top 10%
Top 10%
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