Identification and characterization of a novel transcript down‐regulated in Dlx1/Dlx2 and up‐regulated in Pax6 mutant telencephalon
Copyright policy )Identification and characterization of a novel transcript down‐regulated in Dlx1/Dlx2 and up‐regulated in Pax6 mutant telencephalon
AbstractBy using a custom‐made array containing cDNAs preferentially expressed in the mouse embryonic telencephalon (Porteus et al. [] Brain Res Mol Brain Res 12:7–22; and Alessandro Bulfone, unpublished data), we studied the gene expression profile of the Dlx1/Dlx2−/− subpallium and Pax6−/− pallium. We identified a transcript corresponding to Unigene Cluster Mm.94021 and rat Evf‐1, which is down‐regulated in the Dlx1/Dlx2−/− subpallium and up‐regulated in the Pax6−/− pallium. Here, we report the expression pattern of this transcript, designated mouse Evf1 (mEvf1), in the prenatal forebrain of wild‐type, Dlx1/Dlx2−/− and Pax6−/− mice using RNA in situ hybridization and reverse transcriptase‐polymerase chain reaction. In the wild‐type forebrain mEvf1 expression is restricted to the ventral thalamus, hypothalamus, and subpallial telencephalon (caudal, lateral, and medial ganglionic eminences and septal primordia), whereas it is down‐regulated in the Dlx1/Dlx2−/− subpallium (mainly in caudal, lateral, and medial ganglionic eminences), and up‐regulated in the Pax6−/− lateral and ventral pallium at embryonic day 12.5 and in the dorsal, lateral, and ventral pallium at embryonic day 14.5. Developmental Dynamics 231:614–620, 2004. © 2004 Wiley‐Liss, Inc.
- Telethon Institute Of Genetics And Medicine Italy
- University of California, San Francisco United States
- University of Edinburgh United Kingdom
Homeodomain Proteins, Mice, Knockout, Telencephalon, DNA, Complementary, Genome, Time Factors, PAX6 Transcription Factor, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Embryonic Development, Gene Expression Regulation, Developmental, Repressor Proteins, Mice, Mutation, Animals, Paired Box Transcription Factors, Eye Proteins, In Situ Hybridization, Body Patterning, Oligonucleotide Array Sequence Analysis
Homeodomain Proteins, Mice, Knockout, Telencephalon, DNA, Complementary, Genome, Time Factors, PAX6 Transcription Factor, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Embryonic Development, Gene Expression Regulation, Developmental, Repressor Proteins, Mice, Mutation, Animals, Paired Box Transcription Factors, Eye Proteins, In Situ Hybridization, Body Patterning, Oligonucleotide Array Sequence Analysis
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