Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway
Copyright policy )Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway
We found that Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch for binding to a DNA binding protein RBP-J and suppressed the transactivation activity of Notch signaling. Although MINT null mutant mice were embryonic lethal, MINT-deficient splenic B cells differentiated about three times more efficiently into marginal zone B cells with a concomitant reduction of follicular B cells. MINT is expressed in a cell-specific manner: high in follicular B cells and low in marginal zone B cells. Since Notch signaling directs differentiation of marginal zone B lymphocytes and suppresses that of follicular B lymphocytes in mouse spleen, the results indicate that high levels of MINT negatively regulate Notch signaling and block differentiation of precursor B cells into marginal zone B cells. MINT may serve as a functional homolog of Drosophila Hairless.
Transcriptional Activation, Immunology, B-Lymphocyte Subsets, Mice, Immunology and Allergy, Animals, Drosophila Proteins, Mice, Knockout, B-Lymphocytes, Receptors, Notch, Membrane Proteins, Nuclear Proteins, RNA-Binding Proteins, Cell Differentiation, DNA-Binding Proteins, Infectious Diseases, Liver, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Gene Targeting, Drosophila, Cell Adhesion Molecules, Protein Binding, Signal Transduction
Transcriptional Activation, Immunology, B-Lymphocyte Subsets, Mice, Immunology and Allergy, Animals, Drosophila Proteins, Mice, Knockout, B-Lymphocytes, Receptors, Notch, Membrane Proteins, Nuclear Proteins, RNA-Binding Proteins, Cell Differentiation, DNA-Binding Proteins, Infectious Diseases, Liver, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Gene Targeting, Drosophila, Cell Adhesion Molecules, Protein Binding, Signal Transduction
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