Genomic Organization, Expression, and Chromosomal Mapping of the Mouse Adrenomedullin Gene
Copyright policy )Genomic Organization, Expression, and Chromosomal Mapping of the Mouse Adrenomedullin Gene
We have isolated and characterized the mouse adrenomedullin (AM) gene (Adm) and determined its chromosomal location. The gene spans approximately 2.1 kb and is organized into four exons separated by three introns. The transcription start site was determined to be the adenine nucleotide at -618. The mouse AM 5'-flanking region contains a TATA box-like sequence and several cis-acting regulatory elements. Analysis of the nucleotide and deduced amino acid sequences revealed that mouse preproAM is a 184-amino-acid polypeptide, from which AM and proAM N-terminal 20 peptide are cleaved. Using restriction fragment length variants on a DNA panel of interspecific backcross mice, we mapped Adm to a distal region of mouse chromosome 7.
- University of California, Davis United States
- Duke University United States
- Kyoto University Japan
- University of Tokyo Japan
Mice, Inbred C3H, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Muridae, Adrenomedullin, Mice, Genes, Species Specificity, Animals, Amino Acid Sequence, Protein Precursors, Peptides, Crosses, Genetic, Polymorphism, Restriction Fragment Length
Mice, Inbred C3H, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Muridae, Adrenomedullin, Mice, Genes, Species Specificity, Animals, Amino Acid Sequence, Protein Precursors, Peptides, Crosses, Genetic, Polymorphism, Restriction Fragment Length
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