DCC's function takes shape in the nervous system
Copyright policy )DCC's function takes shape in the nervous system
Deleted in colorectal cancer (DCC), a candidate tumor-suppressor gene, has recently been found to encode a netrin receptor required for axon guidance in vitro. Mutations in Caenorhabditis elegans and Drosophila genes encoding DCC-related proteins affect axon guidance, and these phenotypes resemble those of mutations in netrin genes. Netrins and their DCC-related receptors thus play an evolutionarily conserved role in midline guidance, and DCC may be required more generally for cellular morphogenesis.
- Vanderbilt University Medical Center United States
- Howard Hughes Medical Institute United States
Tumor Suppressor Proteins, Molecular Sequence Data, Receptors, Cell Surface, DCC Receptor, Axons, Genes, DCC, Animals, Humans, Nervous System Physiological Phenomena, Amino Acid Sequence, Cell Adhesion Molecules
Tumor Suppressor Proteins, Molecular Sequence Data, Receptors, Cell Surface, DCC Receptor, Axons, Genes, DCC, Animals, Humans, Nervous System Physiological Phenomena, Amino Acid Sequence, Cell Adhesion Molecules
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