Visualizing the regulation of SLC34 proteins at the apical membrane
Copyright policy )Visualizing the regulation of SLC34 proteins at the apical membrane
The cloning of the renal NaPi-2a (SLC34A1) and NaPi-2c (SLC34A3) phosphate transporters has made it possible to characterize the molecular and biophysical regulation of renal proximal tubular reabsorption of inorganic phosphate (Pi). Dietary factors, such as Pi and K, and several hormones and phosphatonins, including parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and glucocorticoids, regulate the transporters through various transcriptional, translational, and post-translational mechanisms that involve acute trafficking via endocytosis or exocytosis, interactions with PDZ domain proteins, lipid microdomains, and diffusion and clustering in the apical brush border membrane. The visualization of these trafficking events by means of novel microscopy techniques that includes fluorescence lifetime imaging microscopy (FLIM), Förster resonance energy transfer (FRET), fluctuation correlation spectroscopy (FCS), and modulation tracking (MT), is the primary focus of this review.
- University of California, San Francisco United States
- Georgetown University United States
- University of California, Irvine United States
570, Kidney Disease, Physiology, 1.1 Normal biological development and functioning, Forster resonance energy transfer, Medical Physiology, Type II, NaPi-PDZ protein interactions, Phosphates, Kidney Tubules, Proximal, Sodium-Phosphate Cotransporter Proteins, Type II, Medical physiology, Animals, Humans, NaPi-lipid interactions, NaPi transporter diffusion and clustering, Cell Membrane, Proximal, Sodium-Phosphate Cotransporter Proteins, Human Movement and Sports Sciences, Biological Sciences, Fluctuation correlation spectroscopy, Fibroblast Growth Factor-23, Protein Transport, Kidney Tubules, Förster resonance energy transfer, Biochemistry and cell biology, Biochemistry and Cell Biology, Generic health relevance, Fluorescence lifetime imaging microscopy, Zoology
570, Kidney Disease, Physiology, 1.1 Normal biological development and functioning, Forster resonance energy transfer, Medical Physiology, Type II, NaPi-PDZ protein interactions, Phosphates, Kidney Tubules, Proximal, Sodium-Phosphate Cotransporter Proteins, Type II, Medical physiology, Animals, Humans, NaPi-lipid interactions, NaPi transporter diffusion and clustering, Cell Membrane, Proximal, Sodium-Phosphate Cotransporter Proteins, Human Movement and Sports Sciences, Biological Sciences, Fluctuation correlation spectroscopy, Fibroblast Growth Factor-23, Protein Transport, Kidney Tubules, Förster resonance energy transfer, Biochemistry and cell biology, Biochemistry and Cell Biology, Generic health relevance, Fluorescence lifetime imaging microscopy, Zoology
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