Destruction of RhoA CULtivates Actin
Copyright policy )Destruction of RhoA CULtivates Actin
Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.
- Sanford Burnham Prebys Medical Discovery Institute United States
Xenopus, Gastrulation, Ubiquitination, Cell Biology, Xenopus Proteins, Cullin Proteins, Actins, Recombinant Proteins, Substrate Specificity, Evolution, Molecular, Cell Movement, Multiprotein Complexes, Stress Fibers, Animals, Drosophila Proteins, Humans, rhoA GTP-Binding Protein, Molecular Biology, Cell Shape, Protein Processing, Post-Translational, Conserved Sequence
Xenopus, Gastrulation, Ubiquitination, Cell Biology, Xenopus Proteins, Cullin Proteins, Actins, Recombinant Proteins, Substrate Specificity, Evolution, Molecular, Cell Movement, Multiprotein Complexes, Stress Fibers, Animals, Drosophila Proteins, Humans, rhoA GTP-Binding Protein, Molecular Biology, Cell Shape, Protein Processing, Post-Translational, Conserved Sequence
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