Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion
Copyright policy )Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion
Understanding insulin release Insulin release takes place in two phases: a first rapid burst followed by a series of small exocytic bursts that coincide with pulsatile spikes in cytosolic Ca 2+ levels. The second phase is impaired in patients with type II diabetes, underscoring the importance of understanding its molecular basis. Lees et al. report a mechanism through which TMEM24, a lipid transport protein that concentrates at endoplasmic reticulum–plasma membrane contact sites, regulates the pulsatility of cytosolic Ca 2+ and phosphoinositide signaling. This process in turn regulates pulsatile insulin secretion during the slow insulin release phase. Science , this issue p. eaah6171
- Howard Hughes Medical Institute United States
- National University of Singapore Singapore
- Yale University United States
- National University of Singapore Libraries Singapore
Phosphatidylinositol 4,5-Diphosphate, 610, Endoplasmic Reticulum, Gene Knockout Techniques, Chlorocebus aethiops, Insulin Secretion, Animals, Humans, Insulin, Calcium Signaling, Phosphorylation, EXCHANGE, PHOSPHORYLATION, SITES, Science & Technology, TULIP SUPERFAMILY, IDENTIFICATION, Hydrolysis, BINDING PROTEINS, Cell Membrane, Membrane Proteins, Biological Transport, PHOSPHATIDYLSERINE TRANSPORT, Lipid Metabolism, Multidisciplinary Sciences, PHOSPHOLIPIDS, SMP DOMAINS, COS Cells, Science & Technology - Other Topics, CALCIUM OSCILLATIONS, HeLa Cells
Phosphatidylinositol 4,5-Diphosphate, 610, Endoplasmic Reticulum, Gene Knockout Techniques, Chlorocebus aethiops, Insulin Secretion, Animals, Humans, Insulin, Calcium Signaling, Phosphorylation, EXCHANGE, PHOSPHORYLATION, SITES, Science & Technology, TULIP SUPERFAMILY, IDENTIFICATION, Hydrolysis, BINDING PROTEINS, Cell Membrane, Membrane Proteins, Biological Transport, PHOSPHATIDYLSERINE TRANSPORT, Lipid Metabolism, Multidisciplinary Sciences, PHOSPHOLIPIDS, SMP DOMAINS, COS Cells, Science & Technology - Other Topics, CALCIUM OSCILLATIONS, HeLa Cells
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