The Crystal Structure of Lysin, a Fertilization Protein
Copyright policy )The Crystal Structure of Lysin, a Fertilization Protein
Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg. The structure of lysin, refined at 1.9 angstroms resolution, reveals an α-helical, amphipathic molecule. The surface of the protein exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of aromatic and aliphatic amino acids, and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action.
- University of California, San Diego United States
- University of California, San Diego United States
- Scripps Institution of Oceanography United States
- Scripps Research Institute United States
Models, Molecular, Molecular Sequence Data, Crystallography, X-Ray, Protein Structure, Secondary, Mucoproteins, Mollusca, Computer Graphics, Animals, Amino Acid Sequence, Vitelline Membrane
Models, Molecular, Molecular Sequence Data, Crystallography, X-Ray, Protein Structure, Secondary, Mucoproteins, Mollusca, Computer Graphics, Animals, Amino Acid Sequence, Vitelline Membrane
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