Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco
Copyright policy )Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco
In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol, radiotherapy for index cancer) and genetic parameters (family history of UADT cancers and GSTT1/GSTM1 genotype). The GSTM1/T1 null genotype, seen in 60% patients with MPN versus 33% patients with SPN (P=0.03) had an odds ratio of 3.7 [CI=1.14-11.99; P=0.03] for developing MPN. Tobacco use in the form of smoking with or without chewing, as opposed to only chewing, and regular alcohol intake were the two other factors with almost three fold increased risk for the development of MPN, although, the effect was not statistically significant. All three patients with a family history of UADT cancer developed MPN, suggesting an inherited predisposition.
- Cancer Research Institute United States
- Tata Memorial Hospital India
Adult, Male, Tobacco, Smokeless, Genotype, Smoking, India, Middle Aged, Respiratory Tract Neoplasms, Neoplasms, Multiple Primary, Head and Neck Neoplasms, Risk Factors, Case-Control Studies, Carcinoma, Squamous Cell, Humans, Regression Analysis, Genetic Predisposition to Disease, Aged, Glutathione Transferase
Adult, Male, Tobacco, Smokeless, Genotype, Smoking, India, Middle Aged, Respiratory Tract Neoplasms, Neoplasms, Multiple Primary, Head and Neck Neoplasms, Risk Factors, Case-Control Studies, Carcinoma, Squamous Cell, Humans, Regression Analysis, Genetic Predisposition to Disease, Aged, Glutathione Transferase
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).19 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!