Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor
Copyright policy )Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor
Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.
- Assistance Publique -Hopitaux De Paris France
- Washington University in St. Louis United States
- Hôpital Saint-Louis France
- Jackson Laboratory United States
- Jewish Hospital United States
Plasmacytoma: im, 570, Mice-Inbred-BALB-C: ge, Antibodies, Neoplasm, Genetic Linkage, Genes, MHC Class II, Genes-Immune-Response, Cross Reactions, Cross-Reactions, Linkage-(Genetics), Mice, SUPPORT-U-S-GOVT-P-H-S, Animals, Neoplasms-Experimental: im, Hair Color, SUPPORT-NON-U-S-GOVT, Hair-Color, Genes-Structural, Mice, Inbred BALB C, Neoplasms, Experimental, Phenotype, Antibodies-Neoplasm: ge, Genes, Mice, Inbred DBA, Mice-Inbred-DBA: ge, Plasmacytoma
Plasmacytoma: im, 570, Mice-Inbred-BALB-C: ge, Antibodies, Neoplasm, Genetic Linkage, Genes, MHC Class II, Genes-Immune-Response, Cross Reactions, Cross-Reactions, Linkage-(Genetics), Mice, SUPPORT-U-S-GOVT-P-H-S, Animals, Neoplasms-Experimental: im, Hair Color, SUPPORT-NON-U-S-GOVT, Hair-Color, Genes-Structural, Mice, Inbred BALB C, Neoplasms, Experimental, Phenotype, Antibodies-Neoplasm: ge, Genes, Mice, Inbred DBA, Mice-Inbred-DBA: ge, Plasmacytoma
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