PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases
Copyright policy )PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases
Complementation of a temperature sensitive mutant of the yeast Saccharomyces cerevisiae resulted in the isolation of PTF1 (processing/termination factor 1), an essential gene encoding a putative 3′‐end processing or transcription termination factor of pre‐mRNAs. Ptf1p shows significant homology to a newly discovered family of PPIases. This family is characterized by its insensitivity to immunosuppressive drugs and the lack of homology with cyclophilins and FK‐506 binding proteins [Rahfeld et al. (1994) FEBS Lett. 352, 180–184]. Should Ptf1p display PPIase activity, it would be the first characterized, eukaryotic member of this putative family, which is essential for growth.
Saccharomyces cerevisiae Proteins, Genes, Fungal, Molecular Sequence Data, Restriction Mapping, Saccharomyces cerevisiae, Open Reading Frames, Amino Acid Sequence, DNA, Fungal, Amino Acid Isomerases, Sequence Deletion, Endodeoxyribonucleases, Base Sequence, Sequence Homology, Amino Acid, Genetic Complementation Test, Temperature, Peptidyl-prolyl cis/trans isomerase, Peptidylprolyl Isomerase, NIMA-Interacting Peptidylprolyl Isomerase, Mutagenesis, Sequence homology, Carrier Proteins, Nucleotide sequence, Transcription Factors
Saccharomyces cerevisiae Proteins, Genes, Fungal, Molecular Sequence Data, Restriction Mapping, Saccharomyces cerevisiae, Open Reading Frames, Amino Acid Sequence, DNA, Fungal, Amino Acid Isomerases, Sequence Deletion, Endodeoxyribonucleases, Base Sequence, Sequence Homology, Amino Acid, Genetic Complementation Test, Temperature, Peptidyl-prolyl cis/trans isomerase, Peptidylprolyl Isomerase, NIMA-Interacting Peptidylprolyl Isomerase, Mutagenesis, Sequence homology, Carrier Proteins, Nucleotide sequence, Transcription Factors
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