Brain expression of apurinic/apyrimidinic endonuclease (APE/Ref-1) multifunctional DNA repair enzyme gene in the mouse with special reference to the suprachiasmatic nucleus
Copyright policy )Brain expression of apurinic/apyrimidinic endonuclease (APE/Ref-1) multifunctional DNA repair enzyme gene in the mouse with special reference to the suprachiasmatic nucleus
Multifunctional mammalian apurinic/apyrimidinic endonuclease (APE, also known as redox factor-1; Ref-1) repairs baseless sites of damaged DNA caused by oxidative stress and regulates the redox state of various DNA binding proteins. Here, we examined the expression of APE/Ref-1 m-RNA in the mouse brain by in situ hybridization. We detected APE/Ref-1 transcripts throughout the mouse brain particularly in the clock oscillating neurons of the suprachiasmatic nucleus (SCN), hippocampal pyramidal cells, granular cells, and in monoaminergic neurons. In the circadian center SCN, levels of APE/ref-1 mRNA transcripts were constantly high, and were not influenced by either circadian rhythms or by exposure to light.
- Kobe University Japan
Brain Mapping, Mice, Inbred BALB C, Time Factors, Reverse Transcriptase Polymerase Chain Reaction, Carbon-Oxygen Lyases, Brain, Gene Expression, Immunohistochemistry, Circadian Rhythm, Mice, Spinal Cord, DNA-(Apurinic or Apyrimidinic Site) Lyase, Animals, Autoradiography, Suprachiasmatic Nucleus, RNA, Messenger, In Situ Hybridization
Brain Mapping, Mice, Inbred BALB C, Time Factors, Reverse Transcriptase Polymerase Chain Reaction, Carbon-Oxygen Lyases, Brain, Gene Expression, Immunohistochemistry, Circadian Rhythm, Mice, Spinal Cord, DNA-(Apurinic or Apyrimidinic Site) Lyase, Animals, Autoradiography, Suprachiasmatic Nucleus, RNA, Messenger, In Situ Hybridization
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