Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum
Copyright policy )Cooperativity between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum
11Beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a NADP(H)-dependent oxidoreductase of the ER lumen, which may have an important role in the pathogenesis of metabolic syndrome. Here, the functional coupling of 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase (H6PDH) was investigated in rat liver microsomal vesicles. The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11betaHSD1 and H6PDH based on their co-localization and the mutual generation of cofactors for each other.
- Semmelweis University Hungary
- Hungarian Academy of Sciences Hungary
- University of Siena Italy
Male, rat liver microsomes, Pyridines, 11 beta-hydroxysteroid dehydrogenase type 1, Endoplasmic Reticulum, Rats, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Microsomes, Liver, Animals, Carbohydrate Dehydrogenases, 11 beta-hydroxysteroid dehydrogenase type 1; hexose-6-phosphate dehydrogenase; pyridine nucleotides; rat liver microsomes, Rats, Wistar, Transport Vesicles, hexose-6-phosphate dehydrogenase, pyridine nucleotide
Male, rat liver microsomes, Pyridines, 11 beta-hydroxysteroid dehydrogenase type 1, Endoplasmic Reticulum, Rats, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Microsomes, Liver, Animals, Carbohydrate Dehydrogenases, 11 beta-hydroxysteroid dehydrogenase type 1; hexose-6-phosphate dehydrogenase; pyridine nucleotides; rat liver microsomes, Rats, Wistar, Transport Vesicles, hexose-6-phosphate dehydrogenase, pyridine nucleotide
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