HLA class I and II alleles and response to treatment with interferon-beta in relapsing–remitting multiple sclerosis
Copyright policy )HLA class I and II alleles and response to treatment with interferon-beta in relapsing–remitting multiple sclerosis
In the present study, we investigated the influence of HLA class I and class II genes in the response to interferon-beta (IFNbeta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFNbeta responders (n=74) and non-responders (n=75) based on stringent clinical criteria. Distribution of HLA class I and class II alleles individually and the HLA-DR2 haplotype was similar between responders and non-responders to treatment. These findings do not support a role of the HLA class I and class II genes as modifiers of the response to IFNbeta.
Adult, Male, Genotype, DNA Mutational Analysis, Histocompatibility Antigens Class I, Drug Resistance, Histocompatibility Antigens Class II, Interferon-beta, Cohort Studies, Multiple Sclerosis, Relapsing-Remitting, Gene Frequency, Haplotypes, Predictive Value of Tests, Humans, Immunologic Factors, Female, Genetic Testing
Adult, Male, Genotype, DNA Mutational Analysis, Histocompatibility Antigens Class I, Drug Resistance, Histocompatibility Antigens Class II, Interferon-beta, Cohort Studies, Multiple Sclerosis, Relapsing-Remitting, Gene Frequency, Haplotypes, Predictive Value of Tests, Humans, Immunologic Factors, Female, Genetic Testing
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