Cloning of a Novel Human Testis mRNA Specifically Expressed in Testicular Haploid Germ Cells, Having Unique Palindromic Sequences and Encoding a Leucine Zipper Dimerization Motif
Copyright policy )Cloning of a Novel Human Testis mRNA Specifically Expressed in Testicular Haploid Germ Cells, Having Unique Palindromic Sequences and Encoding a Leucine Zipper Dimerization Motif
A novel gene coding for a human sperm surface protein (HSS) has been cloned from a human testis cDNA library. The 2.5 kb cDNA (hss) contains five direct repeats, three mirror repeats, three possible stem loop structures and three unique palindromic motifs located at functionally relevant positions. Open reading frame encodes a protein of 766 amino acids. The deduced protein analysis revealed a NH2 terminus extracellular domain having a leucine zipper (LZ) motif, a transmembrane helical domain and a cytoplasmic domain at the COOH terminus. Tissue specific expression studies demonstrated the presence of hss transcript only in testis. Cell type expression of hss mRNA was observed only on the round spermatids suggesting haploid germ cell expression.
Male, Leucine Zippers, Base Sequence, Molecular Sequence Data, Membrane Proteins, Sequence Analysis, DNA, Spermatozoa, Gene Expression Regulation, Testis, Humans, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Spermatogenesis, Dimerization, In Situ Hybridization, Adaptor Proteins, Signal Transducing
Male, Leucine Zippers, Base Sequence, Molecular Sequence Data, Membrane Proteins, Sequence Analysis, DNA, Spermatozoa, Gene Expression Regulation, Testis, Humans, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Spermatogenesis, Dimerization, In Situ Hybridization, Adaptor Proteins, Signal Transducing
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).45 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!