Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?
Copyright policy )Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?
Inadequate healing of myocardial infarction may contribute to local expansion of the infarct, frequently leading to chamber dilation, heart failure, or myocardial rupture. Experimental evidence in mouse models suggests that Factor XIII might play a key role in wound healing, and low persistent values lead to increased incidence of cardiac rupture following myocardial infarction. Here we would like to share our initial clinical experiences with strikingly similar observations in patients with this grave disease, and compare these observations to experimental findings.
- Harvard University United States
- Massachusetts General Hospital United States
- Harvard Medical School United States
- University of Würzburg Germany
- Center for Molecular Imaging Research Massachusetts General Hospital Harvard Medical School United States
Mice, Knockout, Wound Healing, cardiovascular disorders, Science, Q, R, Models, Cardiovascular, Myocardial Infarction, 610, Factor XIII Deficiency, Disease Models, Animal, Mice, radiology and medical imaging, cardiac surgery and transplantations, 616, Medicine, Animals, Humans, Research Article, Heart Rupture, Post-Infarction
Mice, Knockout, Wound Healing, cardiovascular disorders, Science, Q, R, Models, Cardiovascular, Myocardial Infarction, 610, Factor XIII Deficiency, Disease Models, Animal, Mice, radiology and medical imaging, cardiac surgery and transplantations, 616, Medicine, Animals, Humans, Research Article, Heart Rupture, Post-Infarction
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