TARP γ-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
Copyright policy )TARP γ-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
Synaptic plasticity involves activity-dependent trafficking of AMPA-type glutamate receptors. Numerous cytoplasmic scaffolding proteins are postulated to control AMPA receptor trafficking, but the detailed mechanisms remain unclear. Here, we show that the transmembrane AMPA receptor regulatory protein (TARP) gamma-8, which is preferentially expressed in the mouse hippocampus, is important for AMPA receptor protein levels and extrasynaptic surface expression. By controlling the number of AMPA receptors, gamma-8 is also important in long-term potentiation, but not long-term depression. This study establishes gamma-8 as a critical protein for basal AMPA receptor expression and localization at extrasynaptic sites in the hippocampus and raises the possibility that TARP-dependent control of AMPA receptors during synapse development and plasticity may be widespread.
- University of California, San Francisco United States
- National Institute of Health Pakistan
- National Institutes of Health United States
- National Institute on Deafness and Other Communication Disorders United States
Mice, Knockout, Kainic Acid, Neuronal Plasticity, Blotting, Western, Green Fluorescent Proteins, Excitatory Postsynaptic Potentials, Dose-Response Relationship, Radiation, In Vitro Techniques, Blotting, Northern, Hippocampus, Immunohistochemistry, Electric Stimulation, Membrane Potentials, Mice, Inbred C57BL, Blotting, Southern, Mice, Gene Expression Regulation, Excitatory Amino Acid Agonists, Animals, Microscopy, Immunoelectron
Mice, Knockout, Kainic Acid, Neuronal Plasticity, Blotting, Western, Green Fluorescent Proteins, Excitatory Postsynaptic Potentials, Dose-Response Relationship, Radiation, In Vitro Techniques, Blotting, Northern, Hippocampus, Immunohistochemistry, Electric Stimulation, Membrane Potentials, Mice, Inbred C57BL, Blotting, Southern, Mice, Gene Expression Regulation, Excitatory Amino Acid Agonists, Animals, Microscopy, Immunoelectron
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).257 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!