Lrrk2 and α-synuclein are co-regulated in rodent striatum
Copyright policy )Lrrk2 and α-synuclein are co-regulated in rodent striatum
LRRK2, alpha-synuclein, UCH-L1 and DJ-1 are implicated in the etiology of Parkinson's disease. We show for the first time that increase in striatal alpha-synuclein levels induce increased Lrrk2 mRNA levels while Dj-1 and Uch-L1 are unchanged. We also demonstrate that a mouse strain lacking the dopamine signaling molecule DARPP-32 has significantly reduced levels of both Lrrk2 and alpha-synuclein, while mice carrying a disabling mutation of the DARPP-32 phosphorylation site T34A or lack alpha-synuclein do not show any changes. To test if striatal dopamine depletion influences Lrrk2 or alpha-synuclein expression, we used the neurotoxin 6-hydroxydopamine in rats and MitoPark mice in which there is progressive degeneration of dopamine neurons. Because striatal Lrrk2 and alpha-synuclein levels were not changed by dopamine depletion, we conclude that Lrrk2 and alpha-synuclein mRNA levels are possibly co-regulated, but they are not influenced by striatal dopamine levels.
- Karolinska Institute Sweden
- Lundbeck Germany
Male, Mice, Knockout, Neurons, Dopamine and cAMP-Regulated Phosphoprotein 32, Dopamine, Mice, Transgenic, Parkinson Disease, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Corpus Striatum, Rats, Mice, Inbred C57BL, Rats, Sprague-Dawley, Mice, alpha-Synuclein, Animals, Humans, Female, Oxidopamine
Male, Mice, Knockout, Neurons, Dopamine and cAMP-Regulated Phosphoprotein 32, Dopamine, Mice, Transgenic, Parkinson Disease, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Corpus Striatum, Rats, Mice, Inbred C57BL, Rats, Sprague-Dawley, Mice, alpha-Synuclein, Animals, Humans, Female, Oxidopamine
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).38 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!