Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
Copyright policy )Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
Significance Naturally occurring regulatory T (Treg) cells suppress aberrant or excessive immune responses, thereby maintaining immune self-tolerance and homeostasis. This study shows that a combination of IL-2 repression, CTLA-4 expression, and antigenic stimulation is able to convert conventional T cells to potently immunosuppressive Treg-like cells, which are able to deprive IL-2 and CD28 signal from other T cells. Like natural Treg cells, they acquire a self-skewed T-cell receptor repertoire in the course of their thymic development, enabling them to control autoimmune responses effectively. This Treg construction by targeting IL-2 and CTLA-4 in conventional T cells is a novel way of immune suppression.
Analysis of Variance, Immunity, Cellular, Mice, Inbred BALB C, Autoimmunity, Cell Differentiation, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Dendritic Cells, Flow Cytometry, Inflammatory Bowel Diseases, Binding, Competitive, T-Lymphocytes, Regulatory, Mice, CD28 Antigens, Microscopy, Fluorescence, Animals, Interleukin-2, CTLA-4 Antigen
Analysis of Variance, Immunity, Cellular, Mice, Inbred BALB C, Autoimmunity, Cell Differentiation, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Dendritic Cells, Flow Cytometry, Inflammatory Bowel Diseases, Binding, Competitive, T-Lymphocytes, Regulatory, Mice, CD28 Antigens, Microscopy, Fluorescence, Animals, Interleukin-2, CTLA-4 Antigen
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