Solution structure of the c-terminal core domain of human TFIIB: Similarity to cyclin A and interaction with TATA-binding protein
Copyright policy )Solution structure of the c-terminal core domain of human TFIIB: Similarity to cyclin A and interaction with TATA-binding protein
TFIIB is an essential component of the machinery that transcribes protein-coding genes. The three-dimensional structure of the human TFIIB core domain (TFIIBc) has been determined using multidimensional heteronuclear magnetic resonance spectroscopy. The molecule consists of two direct repeats that adopt similar alpha-helical folds, conferring pseudo-twofold symmetry. An extensive, central basic surface including an amphipathic alpha helix is critical to the function of TFIIB as a bridge between the TBP-promoter complex and RNA polymerase II and associated general and regulatory transcription factors. Similarities between the TFIIBc and cyclin A folds indicate that elements of the eukaryotic cell cycle control apparatus evolved from more fundamental transcriptional control components, demonstrating a link between the transcription and cell cycle molecular machineries.
- University of Medicine and Dentistry of New Jersey United States
- Howard Hughes Medical Institute United States
- Ontario Institute for Cancer Research Canada
- University of Toronto Canada
Binding Sites, Magnetic Resonance Spectroscopy, Sequence Homology, Amino Acid, Transcription, Genetic, Biochemistry, Genetics and Molecular Biology(all), Protein Conformation, Molecular Sequence Data, DNA, TATA-Box Binding Protein, TATA Box, DNA-Binding Proteins, Cyclins, Image Processing, Computer-Assisted, Transcription Factor TFIIB, Humans, Amino Acid Sequence, Promoter Regions, Genetic, Transcription Factors
Binding Sites, Magnetic Resonance Spectroscopy, Sequence Homology, Amino Acid, Transcription, Genetic, Biochemistry, Genetics and Molecular Biology(all), Protein Conformation, Molecular Sequence Data, DNA, TATA-Box Binding Protein, TATA Box, DNA-Binding Proteins, Cyclins, Image Processing, Computer-Assisted, Transcription Factor TFIIB, Humans, Amino Acid Sequence, Promoter Regions, Genetic, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).127 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!