The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study
Copyright policy )The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study
Abstract Recently, Rho GTPases substrates include Rac (Rac1 and Rac2) and Cdc42 that have been reported to exert multiple cellular functions in osteoclasts, the most prominent of which includes regulating the dynamic actin cytoskeleton rearrangements. In addition, natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Although currently, there are reports about the natural product, which could play a therapeutic role in bone loss diseases (osteoporosis and osteolysis) through the regulation of Rac1/2 and Cdc42 during osteoclasts cytoskeletal structuring. There have been several excellent studies for exploring the therapeutic potentials of various natural products for their role in inhibiting cancer cells migration and function via regulating the Rac1/2 and Cdc42. Herein in this review, we try to focus on recent advancement studies for extensively understanding the role of Rho GTPases substrates Rac1, Rac2 and Cdc42 in osteoclastogenesis, as well as therapeutic potentials of natural medicinal products for their properties on the regulation of Rac1, and/or Rac2 and Cdc42, which is in order to inspire drug discovery in regulating osteoclastogenesis.
- Xi’an Jiaotong-Liverpool University China (People's Republic of)
- Johns Hopkins University United States
- Johns Hopkins University United States
- Xi'an Jiaotong University China (People's Republic of)
- Nanjing Drum Tower Hospital China (People's Republic of)
rac1 GTP-Binding Protein, rho GTP-Binding Proteins, Biological Products, Osteoblasts, Osteoclasts, Apoptosis, Cell Differentiation, Osteolysis, Cell Line, rac GTP-Binding Proteins, Biochemical Techniques & Resources, Cell Movement, Osteogenesis, Drug Discovery, Models, Animal, Animals, Humans, Osteoporosis, Molecular Targeted Therapy, cdc42 GTP-Binding Protein, Signal Transduction
rac1 GTP-Binding Protein, rho GTP-Binding Proteins, Biological Products, Osteoblasts, Osteoclasts, Apoptosis, Cell Differentiation, Osteolysis, Cell Line, rac GTP-Binding Proteins, Biochemical Techniques & Resources, Cell Movement, Osteogenesis, Drug Discovery, Models, Animal, Animals, Humans, Osteoporosis, Molecular Targeted Therapy, cdc42 GTP-Binding Protein, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!