Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8
Copyright policy )Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8
Npy1r and Npy2r, the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31-q32. We have now assigned Npy1r and Npy2r to conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity.
- University of Michigan–Ann Arbor United States
- Jackson Laboratory United States
- University of Michigan–Flint United States
Male, 570, Receptors-Neuropeptide-Y: ge, Species-Specificity, Genetic Linkage, 610, Base-Sequence, DNA: ge, Evolution, Molecular, Linkage-(Genetics), Mice, Comparative-Study, Species Specificity, SUPPORT-U-S-GOVT-P-H-S, Animals, Humans, SUPPORT-NON-U-S-GOVT, Chromosomes, Artificial, Yeast, Conserved Sequence, Crosses, Genetic, Base Sequence, Evolution-Molecular, Mice-Inbred-C57BL, Conserved-Sequence, Chromosome Mapping, Crosses-Genetic, DNA, Receptors, Neuropeptide Y, Chromosomes-Human-Pair-4: ge, Mice, Inbred C57BL, Muridae, Chromosome-Mapping, Chromosomes-Yeast-Artificial, Female, Chromosomes, Human, Pair 4, Human
Male, 570, Receptors-Neuropeptide-Y: ge, Species-Specificity, Genetic Linkage, 610, Base-Sequence, DNA: ge, Evolution, Molecular, Linkage-(Genetics), Mice, Comparative-Study, Species Specificity, SUPPORT-U-S-GOVT-P-H-S, Animals, Humans, SUPPORT-NON-U-S-GOVT, Chromosomes, Artificial, Yeast, Conserved Sequence, Crosses, Genetic, Base Sequence, Evolution-Molecular, Mice-Inbred-C57BL, Conserved-Sequence, Chromosome Mapping, Crosses-Genetic, DNA, Receptors, Neuropeptide Y, Chromosomes-Human-Pair-4: ge, Mice, Inbred C57BL, Muridae, Chromosome-Mapping, Chromosomes-Yeast-Artificial, Female, Chromosomes, Human, Pair 4, Human
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