Isoforms of Protein Kinase C and Their Distribution in Human Adrenal Cortex and Tumors
Copyright policy )Isoforms of Protein Kinase C and Their Distribution in Human Adrenal Cortex and Tumors
The cytosol and microsomal fractions of human adrenal cortex contain 3 isoforms of protein kinase C: alpha, zeta, and epsilon. The latter fraction is present in trace amounts. No isoforms beta1, beta2, gamma and delta were found in these cell fractions. The distribution of alpha-isoform between the cytosol and microsomal fraction is determined by tissue origin: in normal tissue its content differs by no more than 10%, while in most tumors this isoform is translocated into the microsomal fraction. The distribution of zeta-isoform did not depend on tissue origin.
- Institute of Endocrinology and Metabolism Ukraine
- National Academy of Medical Sciences of Ukraine Ukraine
- Academy of Medical Sciences United Kingdom
- National Academy of Sciences of Ukraine Ukraine
Hyperplasia, Protein Kinase C-alpha, Blotting, Western, Adrenal Cortex Neoplasms, Isoenzymes, Protein Transport, Cytosol, Microsomes, Adrenal Cortex, Humans, Protein Isoforms, Tissue Distribution, Protein Kinase C, Densitometry
Hyperplasia, Protein Kinase C-alpha, Blotting, Western, Adrenal Cortex Neoplasms, Isoenzymes, Protein Transport, Cytosol, Microsomes, Adrenal Cortex, Humans, Protein Isoforms, Tissue Distribution, Protein Kinase C, Densitometry
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